Dysregulation of axonal transport and motorneuron diseases
نویسندگان
چکیده
منابع مشابه
Axonal Transport and Neurodegenerative Diseases 1199 Axonal Transport and Neurodegenerative Diseases
The primary functions of the neuron are to receive, process, and transmit information. A typical neuron has multiple dendrites and a single elongated process, the axon. The dendrites and the cell bodies play a role in the collection and processing of information, and the axon is responsible for the transmission of information to other neurons via synapses. Whereas dendrites are usually in close...
متن کاملPathologies of Axonal Transport in Neurodegenerative Diseases.
Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections and formation of new ones. Proteins described as molecular motors mediate this transport and utilize specialized cytoskeletal proteins that function as molecular tracks for the motor based transport of cargos. Molecular motors such as kinesin...
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Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments and associated with hippocampal degenerative changes, include neurodegenerative process and decreased number of living cell. Mitochondrial Diabetes (MD) appears fallowing activation of mutant mitochondrial DNA and is combination of diabetes and cognitive deficit. In this research we showed the correlation...
متن کاملAxonal transport defects in neurodegenerative diseases.
Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of neurological disorders characterized by a progressive, age-dependent decline in neuronal function and loss of selected neuronal populations. Alterations in synaptic function and axonal connectivity represent early and critical pathogenic events in AONDs, but molecular mechanisms underlying these defects remain elus...
متن کاملDisruption of Axonal Transport in Motor Neuron Diseases
Motor neurons typically have very long axons, and fine-tuning axonal transport is crucial for their survival. The obstruction of axonal transport is gaining attention as a cause of neuronal dysfunction in a variety of neurodegenerative motor neuron diseases. Depletions in dynein and dynactin-1, motor molecules regulating axonal trafficking, disrupt axonal transport in flies, and mutations in th...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2011
ISSN: 0248-4900
DOI: 10.1042/bc20100093